pentobarbital will lessen the extent or impact of venetoclax by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or effect of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Lowered AUC of tramadol along with the active metabolite (O-desmethyltramadol) when